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HIV inserts into human genome using a DNA-associated protein
A human DNA-associated protein called LEDGF is the first such molecule found to control the location of HIV integration in human cells, according to a new study from researchers at the University of ...


DNA patterns
DNA is a versatile molecule with many potential technological applications because it can organize itself into all manner of useful patterns...


Buckyballs could disrupt functioning of DNA
Computer simulations suggest there is a risk the football-shaped nanoparticles could bind to DNA and interfere with the molecule's ability to repair itself


New look at DNA hints at origin of ultraviolet damage
Chemists at Ohio State University have gained new insight into how sunlight affects DNA. And what they found overturns ideas about genetic mutation that originated decades ago. In the current issue of the journal Nature, Bern Kohler and his colleagues report that DNA dissipates the energy from ultraviolet (UV) radiation in a kind of energy wave that travels up the edge of the DNA molecule, as if the energy were climbing one side of the helical DNA "ladder."


ASU researchers 'wire' DNA to identify mutations
A team of ASU researchers led by Nongjian Tao and Peiming Zhang has developed a new, breakthrough technique for the detection of DNA mutations.Their results, published in the journal Proceedings of the National Academy of Sciences, demonstrate for the first time, the possibility of directly identifying these mutations, or single nucleotide polymorphisms (SNPs), by means of measuring the electrical conductance of a single DNA molecule.


Brownian Dynamics Simulation of Knot Diffusion along Stretched DNA Molecule.
Publication Date: 2005 Dec 16 PMID: 16361333Authors: Vologodskii, A.Journal: Biophys JManipulation of individual DNA molecules by optical tweezers made it possible to tie these molecules in different knots. After stretching the DNA molecules the knots become highly localized. In their resent study Quake and co-authors studied diffusion of such knots along stretched DNA molecules. We used these data to test the accuracy of Brownian dynamics simulation of DNA bending motion. We simulated stretched DNA molecules with knots 31, 41 and 71, and determined their diffusion coefficients. Comparison of the simulated and experimental results shows that DB simulation is capable to predict the rates of large-scale DNA rearrangements within factor of 2.